nicotinamide – Communicable Diseases Research

Modeling studies on the role of vitamins B1 (thiamin), B3 (nicotinamide), B6 (pyridoxamine), and caffeine as potential leads for the drug design against COVID-19

Article

Published on 2022-11-072022-11-15
Journal: Journal of molecular modeling
[Category] SARS, 신약개발, 치료제,

Dysregulated miRNAs network in the critical COVID-19: An important clue for uncontrolled immunothrombosis/thromboinflammation

중요한 COVID-19에서 조절되지 않는 miRNA 네트워크: 통제되지 않는 면역혈전증/혈전염증에 대한 중요한 단서

Review

Published on 2022-09-012022-09-11
Journal: International immunopharmacology
[Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료기술,

[키워드] accompanied activated Activation adenine affecting anti-inflammatory factors Anticoagulant cause clinical complication Coagulation Coagulation system complement complement system Complication components conserved coronavirus disease Coronavirus disease 2019 COVID-19 Critical Cytokine storm Defensive mechanism deviation diffusion Effect expression expression level facilitate Factor function Genetic higher risk homeostasis hyperinflammation immune immunothrombosis incidence Interaction involved life-threatening mechanism microRNA MicroRNAs miRNA miRNAs miRNAs-based therapy. molecules Mortality NADPH nicotinamide nicotinamide adenine dinucleotide Nicotinamide adenine dinucleotide phosphate Non-coding RNAs nucleotide oxygen Pathogens Patient phosphate reactive oxygen species reactive oxygen specy reduction response restrict SARS-CoV-2 severe complications therapeutic approach therapy Thromboinflammation thrombotic underlie vicious cycle
[DOI] 10.1016/j.intimp.2022.109040 PMC 바로가기 [Article Type] Review

G6PD deficiency: imbalance of functional dichotomy contributing to the severity of COVID-19

G6PD 결핍: COVID-19의 중증도에 기여하는 기능적 이분법의 불균형

Review

Published on 2022-09-012022-09-11
Journal: Future Microbiology
[Category] 유전자 메커니즘,

Ferulic acid and berberine, via Sirt1 and AMPK, may act as cell cleansing promoters of healthy longevity

Sirt1과 AMPK를 통한 페룰산과 베르베린은 건강한 장수의 세포 정화 촉진제로 작용할 수 있습니다

Review

Published on 2022-03-012022-09-11
Journal: Open Heart
[Category] SARS, 유전자 메커니즘, 치료기술,

[키워드] activating Activation AMPK amplify amplifying anthocyanin Anti-inflammatory effects antioxidant Apoptosis appear autophagy bacterial metabolite benefit berberine biogenesis boost carotid carotid artery carotid artery diseases Cell cell survival cellular cellular senescence Chinese clinically complementary Concentration conjunction coronary angiography deficit detect DNA DNA repair echocardiography echocardiography. Effect endothelial ENhance enzyme expression ferulic acid function functions Health health benefits healthy independent Inflammation inhibiting mechanism mediator mitochondrial molecular basis mRNA NAD+ NF-kB nicotinamide Nrf2 nutraceutical Phase 2 promote promoter Protective protective effect protein level protein levels SARS-CoV-2 spike protein SIRT1 Spike protein survival synergistic the SARS-CoV-2 tissues Toxicity transcription factor turn
[DOI] 10.1136/openhrt-2021-001801 PMC 바로가기 [Article Type] Review

eNAMPT neutralization reduces preclinical ARDS severity via rectified NFkB and Akt/mTORC2 signaling

Article

Published on 2022-01-132022-10-29
Journal: Scientific Reports
[Category] Coronavirus,

Analysis of endogenous oxidative damage markers and association with pulmonary involvement severity in patients with SARS-CoV-2 pneumonia

SARS-CoV-2 폐렴 환자에서 내인성 산화 손상 표지자 및 폐 침범 중증도와의 연관성 분석

Article

Published on 2021-08-012022-09-11
Journal: Infectious diseases now
[Category] MERS, 바이오마커,

[키워드] Affect albumin albumin level association caused coenzyme Q10 control group CoQ10 COVID-19 CRP levels determined by ELISA assay ferritin healthy control healthy volunteers high-pressure liquid chromatography Inflammation Ischemia Liquid chromatography Lungs malondialdehyde marker MDA nicotinamide no significant difference NOX4 organs oxidative damage parameter Patient patients with pneumonia patients with SARS-CoV-2 Pneumonia positively correlated pulmonary involvement SARS-CoV-2 SARS-CoV-2 pneumonia SARS-CoV-2 virus SARS-CoV-2. severe pulmonary involvement severity significant difference significantly significantly higher widespread
[DOI] 10.1016/j.idnow.2021.06.302 PMC 바로가기 [Article Type] Article

Combined Metabolic Activators Accelerates Recovery in Mild‐to‐Moderate COVID‐19

결합 된 대사 활성화 제는 온화한 중등도의 CovID -19에서 회복을 가속화합니다

Clinical Trial

Published on 2021-06-282022-08-13
Journal: Advanced Science
[Category] MERS, 임상,

[키워드] accelerate activator adenine administration ambulatory patient ambulatory patients Amino acid antioxidant antioxidant metabolism changes Clinical data clinical trial CMAs Combined combined metabolic activator combined metabolic activators complete recovery comprehensive analysis conducted COVID‐19 COVID‐19 patients deficiencies deficiency double‐blinded phase effective glutathione glutathione metabolism immune response IMPROVE include Infection Inflammation inflammatory proteomics investigated l ‐carnitine l ‐carnitine tartrate lead lipid metabolism metabolic metabolic abnormalities metabolic function metabolism metabolite metabolites metabolomics mitochondrial mitochondrial dysfunction mixture NAD+ nicotinamide nicotinamide adenine dinucleotide nicotinamide riboside omics data Open‐label phase Patient patients treated Phase 2 phase 3 trial Phase 3 trials phase‐2 phase‐3 Placebo placebo group Placebo‐controlled Plasma level Plasma levels plasma metabolome plasma metabolomics precursor Protein proteome proteomics regulate respiratory respiratory problems reveal Safe salt shown significantly significantly shorter therapeutic regime therapeutic strategy Treatment
[DOI] 10.1002/advs.202101222 PMC 바로가기 [Article Type] Clinical Trial

Endothelial eNAMPT amplifies pre-clinical acute lung injury: efficacy of an eNAMPT-neutralising monoclonal antibody

내피 eNAMPT는 전임상 급성 폐 손상을 증폭합니다: eNAMPT 중화 단일클론 항체의 효능

Article

Published on 2021-05-062022-09-11
Journal: The European Respiratory Journal
[Category] Fulltext, SARS, 진단, 치료기술, 치료제,

[키워드] abrogate Activation acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome amplify antibody ARDS assays BAL biochemical biologic Biomarker Bronchoalveolar lavage cells Combination coronavirus coronavirus disease demonstrated detect disease effective therapy Efficacy Endothelial cell eosin expression Extracellular genotyping Haematoxylin highlight human lung identify in vitro in vivo increases in Inflammation Inflammatory inflammatory lung injury Innate immunity interleukin-6 knockout mice Ligand lipopolysaccharide lung Lung injury lung tissue lung tissues mAb master regulator mice monoclonal antibody Mortality NAMPT Neutralising Antibodies nicotinamide offer pandemic pathway personalised plasma polyclonal polyclonal antibody polymorphonuclear Predictive probe Protein receptor reduce respiratory respiratory distress severe acute respiratory syndrome Coronavirus severity significantly staining subject syndrome therapeutic target TLR4 Toll-like receptor unmet need was used were used wild-type
[DOI] 10.1183/13993003.02536-2020 PMC 바로가기 [Article Type] Article

Metabolic Signatures Associated with Severity in Hospitalized COVID-19 Patients

입원한 COVID-19 환자의 중증도와 관련된 대사 신호

Observational Study

Published on 2021-04-302022-09-10
Journal: International Journal of Molecular Sciences
[Category] MERS, SARS, 바이오마커, 임상,

[키워드] adenine adenine nucleotide Admission assist association Barcelona Biomarker Biomarkers blood pressure ceramide Ceramides change clinical evolution collected correlated COVID-19 COVID-19 patient COVID-19 pneumonia Critical Degradation demographic disease severity enrolled evaluate Evolution Hospitalization hospitalized COVID-19 patients hospitalized patient identifying Inclusion Inflammation Kynurenine metabolic metabolic pathway metabolic pathways metabolism metabolomic metabolomics moderate nicotinamide obesity oxygen oxygen saturation parameter pathophysiology plasma samples Pneumonia radiological reaction reductions reductions in Registered respiratory respiratory rate respiratory severity severity signature significantly single-center study Spain Stratification stratified subsequent Tryptophan Viral viral infection was measured with COVID-19
[DOI] 10.3390/ijms22094794 PMC 바로가기 [Article Type] Observational Study

Role of Hydrogen Bonds in Formation of Co-amorphous Valsartan/Nicotinamide Compositions of High Solubility and Durability with Anti-hypertension and Anti-COVID-19 Potential

항고혈압 및 항-COVID-19 잠재성을 지닌 높은 용해도 및 내구성을 갖는 공동-비정질 발사르탄/니코틴아미드 조성물의 형성에서 수소 결합의 역할

Article

Published on 2021-04-012022-08-31
Journal: Molecular Pharmaceutics
[Category] 치료제,

[키워드] (nicotinamide) acting active pharmaceutical ingredient analyses angiotensin Angiotensin II anti-hypertensive applied approaches Bioavailability bond caused characterized co-amorphization conformational change conformational changes coronavirus COVID-19 Density functional theory Donor drug drugs Effects Efficacy exhibit flexible Formation functional heterodimeric hydrogen Hydrogen bond hydrogen bonds hypertension ingredient Interaction key factor liquid low molecular weight lung market molecules NIC nicotinamide pandemic coronavirus Physicochemical properties Potential quantum theory receptor receptor blocker responsible role SARS-COV-2 infection solid dispersion solubility treat valsartan X-ray
[DOI] 10.1021/acs.molpharmaceut.0c01096 PMC 바로가기 [Article Type] Article